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Tanis: a link between type 2 diabetes and inflammation?
journal contribution
posted on 2002-06-01, 00:00 authored by Ken WalderKen Walder, Lakshmi Kantham, J McMillan, J Trevaskis, L Kerr, A de Silva, T Sunderland, Nathan Godde, Yuan Gao, N Bishara, Kelly WindmillKelly Windmill, Janette Tenne-Brown, G Augert, P Zimmet, Gregory CollierHere we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin levels (P = 0.004) and in direct proportion with plasma triglyceride concentrations (P = 0.007). Hepatic Tanis gene expression was markedly increased (3.1-fold) after a 24-h fast in diabetic but not in nondiabetic P. obesus. In addition, glucose inhibited Tanis gene expression in cultured hepatocytes (P = 0.006) as well as in several other cell types (P = 0.001–0.011). Thus, Tanis seems to be regulated by glucose and is dysregulated in the diabetic state. Yeast-2 hybrid screening identified serum amyloid A (SAA), an acute-phase inflammatory response protein, as an interacting protein of Tanis, and this was confirmed by Biacore experiments. SAA and other acute-phase proteins have been the focus of recent attention as risk factors for cardiovascular disease, and we contend that Tanis and its interaction with SAA may provide a mechanistic link among type 2 diabetes, inflammation, and cardiovascular disease.
History
Journal
DiabetesVolume
51Issue
6Pagination
1859 - 1866Publisher
American Diabetes AssociationLocation
New York, N.Y.ISSN
0012-1797eISSN
1939-327XLanguage
engNotes
RSD author affiliation updated GH 29 April 2011Publication classification
C1 Refereed article in a scholarly journalCopyright notice
2002, American Diabetes AssociationUsage metrics
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