File(s) under permanent embargo
TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults
journal contribution
posted on 2010-11-01, 00:00 authored by J Du, D Z Fang, J Lin, L Y Xiao, X D Zhou, Sarah ShigdarSarah Shigdar, Wei DuanWei DuanThe aim of this study was to investigate the interactions of genetic variants in the genes of cholesterol ester transfer protein (CETP) and low-density lipoprotein receptor (LDLR) with high carbohydrate and low fat (HC/LF) diet on lipid profiles in a young and healthy Chinese Han population. Fifty-six healthy subjects (22.89±1.80 years) were given washout diets of 31% fat and 54% carbohydrate for 7 days, followed by HC/LF diets of 15% fat and 70% carbohydrate for 6 days, with no total energy restriction. Serum lipid profiles at baseline, after washout and following HC/LF diets, as well as CETP and LDLR polymorphisms were analyzed. Carriers of B2 allele of CETP TaqIB polymorphism had significantly higher levels of high density lipoprotein cholesterol (HDL-C) and apo A-I in the whole study population after the diet intervention. Notably, males with CETP TaqIB B1B1 experienced significantly increased HDL-C and apo A-I after HC/LF diet. Regarding the LDLR Pvu II polymorphism, both P1P1 subjects and P2 carriers experienced decreased total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels after HC/LF diet with no statistically significant differences between the genotypes. Our results demonstrate that the elevated HDL-C levels after HC/LF diet in healthy Chinese Han youth are associated with CETP TaqI B2 allele while males with B1B1 genotype are more susceptible to the influence of HC/LF diet on their HDL-C levels. The decreased TC and LDL-C levels after HC/LF diet are not associated with LDLR Pvu II polymorphism.
History
Journal
Journal of nutritional biochemistryVolume
21Issue
11Pagination
1114 - 1119Publisher
ElsevierLocation
New York, N.Y.Publisher DOI
ISSN
0955-2863eISSN
1873-4847Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2010, ElsevierUsage metrics
Categories
No categories selectedKeywords
cholesterol ester transfer proteinlow-density lipoprotein receptorpolymorphismsserum lipidshigh-carbohydrate\/low-fat dietAdultAllelesApolipoprotein A-IAsian Continental Ancestry GroupCholesterol Ester Transfer ProteinsCholesterol, HDLCholesterol, LDLDiet, Fat-RestrictedDietary CarbohydratesFemaleGenotypeHumansMalePolymorphism, GeneticYoung AdultScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyNutrition & DieteticsESTER TRANSFER PROTEINDENSITY-LIPOPROTEIN CHOLESTEROLCORONARY-ARTERY-DISEASEHIGH-CARBOHYDRATE DIETINTRON 15 POLYMORPHISMLDL RECEPTOR GENELOW-FAT DIETHIGH-RISKMYOCARDIAL-INFARCTIONLIPID CONCENTRATIONS
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC