ujvari-telomeredynamics-2012.pdf (655.79 kB)
Telomere dynamics and homeostasis in a transmissible cancer
journal contribution
posted on 2012-01-01, 00:00 authored by Beata UjvariBeata Ujvari, A M Pearse, R Taylor, S Pyecroft, C Flanagan, S Gombert, A Papenfuss, Thomas MadsenThomas Madsen, K BelovDevil Facial Tumour Disease (DFTD) is a unique clonal cancer that threatens the world's largest carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii) with extinction. This transmissible cancer is passed between individual devils by cell implantation during social interactions. The tumour arose in a Schwann cell of a single devil over 15 years ago and since then has expanded clonally, without showing signs of replicative senescence; in stark contrast to a somatic cell that displays a finite capacity for replication, known as the “Hayflick limit”.
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PLoS oneVolume
7Issue
8Pagination
1 - 8Publisher
Public Library of ScienceLocation
San Fransico, Calif.Publisher DOI
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1932-6203Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2012, Public Library of ScienceUsage metrics
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