nowson-theeffect-2004.pdf (909.55 kB)
The effect of calcium supplementation on bone density in premenarcheal females: a co-twin approach
journal contribution
posted on 2004-01-01, 00:00 authored by M Cameron, L Paton, Caryl NowsonCaryl Nowson, Claire MargerisonClaire Margerison, M Frame, J WarkThe age and developmental stage at which calcium supplementation produces the greatest bone effects remain controversial. We tested the hypothesis that calcium supplementation may improve bone accrual in premenarcheal females. Fifty-one pairs of premenarcheal female twins (27 monozygotic and 24 dizygotic; mean ± SD age, 10.3 ± 1.5 yr) participated in a randomized, single-blind, placebo-controlled trial with one twin of each pair receiving a 1200-mg calcium carbonate (Caltrate) supplement. Areal bone mineral density (aBMD) was measured at baseline and 6, 12, 18 and 24 months. There were no within-pair differences in height, weight, or calcium intake at baseline. Calcium supplementation was associated (P < 0.05) with increased aBMD compared with placebo, adjusted for age, height, and weight at the following time points from baseline: total hip, 6 months (1.9%), 12 months (1.6%), and 18 months (2.4%); lumbar spine, 12 months (1.0%); femoral neck, 6 months (1.9%). Adjusted total body bone mineral content was higher in the calcium group at 6 months (2.0%), 12 months (2.5%), 18 months (4.6%), and 24 months (3.7%), respectively (all P < 0.001). Calcium supplementation was effective in increasing aBMD at regional sites over the first 12–18 months, but these gains were not maintained to 24 months.
History
Journal
Journal of clinical endocrinology and metabolismVolume
89Issue
10Pagination
4916 - 4922Publisher
Endocrine SocietyLocation
Baltimore, MDPublisher DOI
ISSN
0021-972XeISSN
1945-7197Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2004, Endocrine SocietyUsage metrics
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