File(s) under permanent embargo
The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis
journal contribution
posted on 2014-08-01, 00:00 authored by Rasika SamarasingheRasika Samarasinghe, Rupinder Kanwar, Jagat KanwarIn this study, the therapeutic potentials of 100% iron saturated-bovine lactoferrin encapsulated in alginate-chitosan polymeric nanocarriers (AEC-CP-Fe-bLf-NCs) were examined in in vitro inflammatory OA model and in collagen-induced arthritis (CIA) mice. Oral administration of nanocarriers in mice were non-toxic and significantly induced disease modifying activity by reducing joint inflammation and downregulating the expression of catabolic genes, IL-1β, NO, JNK and MAPK. In addition, up-regulation of type II collagen, aggrecan and inflammation depleted iron and calcium metabolisms via inhibition of miRNA of iron transporting receptors was shown in AEC-CP-Fe-bLf-NCs treated mice.
History
Journal
BiomaterialsVolume
35Issue
26Pagination
7522 - 7534Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0142-9612Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2014, ElsevierUsage metrics
Categories
No categories selectedKeywords
osteoarthritisnanomedicinechitosanlactoferrinmiRNAiron metabolismScience & TechnologyTechnologyEngineering, BiomedicalMaterials Science, BiomaterialsEngineeringMaterials ScienceNanocarriersANTIOXIDANT ENZYME-ACTIVITIESGUT EPITHELIAL-CELLSARTICULAR-CARTILAGERHEUMATOID-ARTHRITISOXIDATIVE STRESSCANCER-CHEMOTHERAPYIN-VITROCALCIUMMETABOLISMREGULATOR
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC