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The impact of hypoglycaemia on quality of life and related patient-reported outcomes in Type 2 diabetes : a narrative review
journal contribution
posted on 2012-01-01, 00:00 authored by S Barendse, H Singh, B Frier, Jane SpeightJane SpeightAs a common side effect of insulin treatment for diabetes, hypoglycaemia is a constant threat and can have far-reaching and potentially devastating consequences, including immediate physical injury as well as more pervasive cognitive, behavioural and emotional effects. Moreover, as a significant limiting factor in achieving optimal glycaemic control, exposure to hypoglycaemia can influence diabetes self-management.
Although hypoglycaemia is known to occur in Type 2 diabetes, its morbidity and impact on the individual are not well recognized. The aim of the current review is to examine published evidence to achieve a synthesis of the scope and significance of the potential detriment caused by hypoglycaemia to individuals with Type 2 diabetes. The implications of these observations for treatment and research have also been considered.
A narrative review was performed of empirical papers published in English since 1966, reporting the effect of hypoglycaemia on quality of life and related outcomes (including generic and diabetes specificquality of life, emotional well-being and health utilities) in Type 2 diabetes.
Research demonstrates the potential impact of hypoglycaemia on the lives of people with Type 2 diabetes, from an association with depressive symptoms and heightened anxiety, to impairment of the ability to drive, work and function in ways that are important for quality of life. Few studies consider hypoglycaemia as an explanatory variable in combination with quality of life or related primary endpoints. As a consequence, there is a pressing need for high-quality research into the overall impact of hypoglycaemia on the lives of people with Type 2 diabetes.
Although hypoglycaemia is known to occur in Type 2 diabetes, its morbidity and impact on the individual are not well recognized. The aim of the current review is to examine published evidence to achieve a synthesis of the scope and significance of the potential detriment caused by hypoglycaemia to individuals with Type 2 diabetes. The implications of these observations for treatment and research have also been considered.
A narrative review was performed of empirical papers published in English since 1966, reporting the effect of hypoglycaemia on quality of life and related outcomes (including generic and diabetes specificquality of life, emotional well-being and health utilities) in Type 2 diabetes.
Research demonstrates the potential impact of hypoglycaemia on the lives of people with Type 2 diabetes, from an association with depressive symptoms and heightened anxiety, to impairment of the ability to drive, work and function in ways that are important for quality of life. Few studies consider hypoglycaemia as an explanatory variable in combination with quality of life or related primary endpoints. As a consequence, there is a pressing need for high-quality research into the overall impact of hypoglycaemia on the lives of people with Type 2 diabetes.
History
Journal
Diabetic medicineVolume
29Issue
3Pagination
293 - 302Publisher
Wiley-Blackwell PublishingLocation
Chichester, EnglandPublisher DOI
ISSN
0742-3071eISSN
1464-5491Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2011, Wiley-Blackwell PublishingUsage metrics
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health statustype 2 diabetesquality of lifepatient reported outcomeshypoglycaemiaScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismBLOOD-GLUCOSE AWARENESSCORONARY-HEART-DISEASENOCTURNAL HYPOGLYCEMIAGLYCEMIC CONTROLTREATMENT SATISFACTIONCOGNITIVE FUNCTIONINSULIN THERAPYTREATMENT MODALITIESCRITICAL-APPRAISALRISK-FACTORS
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