tait-inflammatoryresponse-2019.pdf (952.89 kB)
The inflammatory response to simulated day and night emergency alarm mobilisations
journal contribution
posted on 2019-06-21, 00:00 authored by Jamie TaitJamie Tait, Brad AisbettBrad Aisbett, Sarah HallSarah Hall, Luana MainLuana MainPurpose Responding to emergency alarms is a daily occurrence for personnel in safety-critical occupations, and is associated with negative health outcomes in this population. The purpose of the present study was to determine the acute inflammatory response to an isolated emergency alarm mobilisation in both day and night conditions. Methods Sixteen healthy males (mean age 25 ± 4 years) spent four days and nights in a sleep laboratory and were required to mobilise to an emergency alarm either during the day (1558 h), or from nocturnal sleep (0358 h). Pro (TNF-α, IL-1β, IL-8, IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine responses to each alarm mobilisation were compared to time-matched control conditions without the alarm and mobilisation stimulus. Results Analysis revealed no significant drift of cytokine levels at 1400 h across the study (P0.139). The plasma concentration of anti-inflammatory cytokine IL-4 was 84% greater in the 2-h sampling period following night alarm mobilisation compared to a night control of gentle awakening (P = 0.049), no other condition-by-time interactions were observed. The majority of inflammatory concentrations did not significantly change between alarm mobilisation and control conditions, in either day or night trials. Conclusions These findings may reflect the lack of a true emergency (and the perceived stress) for the alarm mobilisation, together with the neutralising effect of different circadian biorhythms on inflammatory cytokine concentrations.
History
Journal
PLoS oneVolume
14Issue
6Article number
e0218732Pagination
1 - 15Publisher
Public Library of ScienceLocation
San Francisco, Calif.Publisher DOI
Link to full text
eISSN
1932-6203Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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CytokinesInflammationPsychological stressImmune responseHeart rateChronobiologyCritical care and emergency medicineCortisolScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsACUTE PSYCHOLOGICAL STRESSPLASMA-CONCENTRATIONHEART-RATEIMMUNEFIREFIGHTERSSLEEPEXPRESSIONHUMANSRISK
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