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The inflammatory response to simulated day and night emergency alarm mobilisations

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journal contribution
posted on 2019-06-21, 00:00 authored by Jamie TaitJamie Tait, Brad AisbettBrad Aisbett, Sarah HallSarah Hall, Luana MainLuana Main
Purpose Responding to emergency alarms is a daily occurrence for personnel in safety-critical occupations, and is associated with negative health outcomes in this population. The purpose of the present study was to determine the acute inflammatory response to an isolated emergency alarm mobilisation in both day and night conditions. Methods Sixteen healthy males (mean age 25 ± 4 years) spent four days and nights in a sleep laboratory and were required to mobilise to an emergency alarm either during the day (1558 h), or from nocturnal sleep (0358 h). Pro (TNF-α, IL-1β, IL-8, IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine responses to each alarm mobilisation were compared to time-matched control conditions without the alarm and mobilisation stimulus. Results Analysis revealed no significant drift of cytokine levels at 1400 h across the study (P0.139). The plasma concentration of anti-inflammatory cytokine IL-4 was 84% greater in the 2-h sampling period following night alarm mobilisation compared to a night control of gentle awakening (P = 0.049), no other condition-by-time interactions were observed. The majority of inflammatory concentrations did not significantly change between alarm mobilisation and control conditions, in either day or night trials. Conclusions These findings may reflect the lack of a true emergency (and the perceived stress) for the alarm mobilisation, together with the neutralising effect of different circadian biorhythms on inflammatory cytokine concentrations.

History

Journal

PLoS one

Volume

14

Issue

6

Article number

e0218732

Pagination

1 - 15

Publisher

Public Library of Science

Location

San Francisco, Calif.

eISSN

1932-6203

Language

eng

Publication classification

C1 Refereed article in a scholarly journal