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The paradoxical population genetics of Plasmodium falciparum
journal contribution
posted on 2002-06-01, 00:00 authored by D L Hartl, S K Volkman, K M Nielsen, Alyssa BarryAlyssa Barry, K P Day, D F Wirth, E A WinzelerAmong the leading causes of death in African children is cerebral malaria caused by the parasitic protozoan Plasmodium falciparum. Endemic forms of this disease are thought to have originated in central Africa 5000-10 000 years ago, coincident with the innovation of slash-and-burn agriculture and the diversification of the Anopheles gambiae complex of mosquito vectors. Population genetic studies of P. falciparum have yielded conflicting results. Some evidence suggests that today's population includes multiple ancient lineages pre-dating human speciation. Other evidence suggests that today's population derives from only one, or a small number, of these ancient lineages. Resolution of this issue is important for the evaluation of the long-term efficacy of drug and immunological control strategies.
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Journal
Trends in ParasitologyVolume
18Issue
6Pagination
266 - 272Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
1471-4922Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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