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The role of luminal factors in prostaglandin protection against ethanol‐induced gastric mucosal injury
journal contribution
posted on 1993-04-01, 00:00 authored by C MALCONTENTI‐WILSON, Fiona AndrewsFiona Andrews, W SILEN, P E O'BRIENProstaglandins (PG) protect the gastric mucosa against damage by several irritants, but the mechanisms remain unclear. A standard rat model of gastric injury induced by 50% ethanol was used to test the hypothesis that PG protection occurs either by increasing luminal fluid volume and hence diluting the irritant, or by production of protective factors within this fluid. Quantitative histology was used to asssess microscopic mucosal damage. The increase in luminal fluid volume in prostaglandin E2 (PGE2)‐treated animals was measured, and the ability of this increased fluid to protect saline‐treated animals via dilution of the irritant was assessed. The transfer of protection by exchange of luminal fluid from PG to non‐PG treated animals was also tested. Results showed that PGE2 induced a specific increase in luminal fluid volume of 45.6%. When given together with ethanol treatment the extra fluid volume was not protective. Removal of luminal fluid after PG and before ethanol treatment did not abolish protection and no protective factor was transferred with the luminal fluid. In conclusion, this study has shown that neither dilution of ethanol by accumulation of luminal fluid nor the presence of luminal factors is responsible for PG protection.
History
Journal
Journal of Gastroenterology and HepatologyVolume
8Issue
2Pagination
123 - 127Publisher
Wiley-Blackwell Publishing AsiaLocation
Richmond, Vic.Publisher DOI
ISSN
0815-9319eISSN
1440-1746Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
1993, Wiley BlackwellUsage metrics
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