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The use of zein in the controlled release of poorly water-soluble drugs

journal contribution
posted on 2019-07-20, 00:00 authored by Phuong TranPhuong Tran, Wei DuanWei Duan, Beom-Jin Lee, Thao T D Tran
Although zein is a natural protein derived from corn, it has attracted much interest in pharmaceutical and biomedical sciences. Recent remarkable investigations on the use of zein in controlled drug delivery have contributed both important knowledge and potential applications of various products, particularly in the delivery of poorly water-soluble drugs. Zein has also been approved by the Food and Drug Administration for oral delivery. Substantial research has been performed to demonstrate the roles and promise of materials containing zein for pharmaceutical applications. Significant efforts have focused on the biodegradable and hydrophobic properties of zein and on technology using zein as a nanocarrier specifically for nanomedicine. However, important issues concerning the use of zein in technical advances and in the development of poorly water-soluble drugs must be addressed in order to use zein in translational research. This review aims to focus on the classification of potential approaches for using zein in the controlled release of poorly water-soluble drugs and to discuss recommended techniques for creating high-quality products from zein.

History

Journal

International journal of pharmaceutics

Volume

566

Pagination

557 - 564

Publisher

Elsevier

Location

Amsterdam, The Netherlands

eISSN

1873-3476

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Elsevier B.V.