berk-towardprecisionpsych-2018.pdf (913.61 kB)
Toward precision psychiatry in bipolar disorder: staging 2.0
journal contribution
posted on 2018-11-01, 00:00 authored by Estela Salagre, Seetal DoddSeetal Dodd, Alberto Aedo, Adriane Rosa, Silvia Amoretti, Justo Pinzon, Maria Reinares, Michael BerkMichael Berk, Flavio Pereira Kapczinski, Eduard Vieta, Iria GrandePersonalized treatment is defined as choosing the "right treatment for the right person at the right time." Although psychiatry has not yet reached this level of precision, we are on the way thanks to recent technological developments that may aid to detect plausible molecular and genetic markers. At the moment there are some models that are contributing to precision psychiatry through the concept of staging. While staging was initially presented as a way to categorize patients according to clinical presentation, course, and illness severity, current staging models integrate multiple levels of information that can help to define each patient's characteristics, severity, and prognosis in a more precise and individualized way. Moreover, staging might serve as the foundation to create a clinical decision-making algorithm on the basis of the patient's stage. In this review we will summarize the evolution of the bipolar disorder staging model in relation to the new discoveries on the neurobiology of bipolar disorder. Furthermore, we will discuss how the latest and future progress in psychiatry might transform current staging models into precision staging models.
History
Journal
Frontiers in psychiatryVolume
9Article number
641Pagination
1 - 15Publisher
Frontiers MediaLocation
Lausanne, SwitzerlandPublisher DOI
Link to full text
ISSN
1664-0640Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, Salagre, Dodd, Aedo, Rosa, Amoretti, Pinzon, Reinares, Berk, Kapczinski, Vieta and GrandeUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC