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Towards a classification of biomarkers of neuropsychiatric disease: From encompass to compass
journal contribution
posted on 2015-02-01, 00:00 authored by J Davis, M. Maes, A Andreazza, J J McGrath, Susannah Tye, Michael BerkMichael BerkThere is currently considerable imprecision in the nosology of biomarkers used in the study of neuropsychiatric disease. The neuropsychiatric field lags behind others such as oncology, wherein, rather than using 'biomarker' as a blanket term for a diverse range of clinical phenomena, biomarkers have been actively classified into separate categories, including prognostic and predictive tests. A similar taxonomy is proposed for neuropsychiatric diseases in which the core biology remains relatively unknown. This paper divides potential biomarkers into those of (1) risk, (2) diagnosis/trait, (3) state or acuity, (4) stage, (5) treatment response and (6) prognosis, and provides illustrative exemplars. Of course, biomarkers rely on available technology and, as we learn more about the neurobiological correlates of neuropsychiatric disorders, we will realize that the classification of biomarkers across these six categories can change, and some markers may fit into more than one category.
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Journal
Molecular PsychiatryVolume
20Issue
2Pagination
152 - 153Publisher DOI
ISSN
1359-4184eISSN
1476-5578Publication classification
C1 Refereed article in a scholarly journal; C Journal articleUsage metrics
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