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Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity
journal contribution
posted on 2008-02-01, 00:00 authored by K Kedzierska, N La Gruta, John StambasJohn Stambas, S Turner, P DohertyAntigen-specific T cell receptors (TCRs) recognise complexes of immunogenic peptides (p) and major histocompatibility complex (MHC) glycoproteins. Responding T cell populations show profiles of preferred usage (or bias) toward one or few TCRβ chains. Such skewing is also observed, though less commonly, in TCRα chain usage. The extent and character of clonal diversity within individual, antigen-specific T cell sets can be established by sequence analysis of the TCRVβ and/or TCRVα CDR3 loops. The present review provides examples of such TCR repertoires in prominent responses to acute and persistent viruses. The determining role of structural constraints and antigen dose is discussed, as is the way that functionally and phenotypically distinct populations can be defined at the clonal level. In addition, clonal dissection of “high” versus “low” avidity, or “central” versus “effector” memory sets provides insights into how these antigen specific T cell responses are generated and maintained. As TCR diversity potentially influences both the protective capacity of CD8+ T cells and the subversion of immune control that leads to viral escape, analysing the spectrum of TCR selection and maintenance has implications for improving the functional efficacy of T cell responsiveness and effector function.
History
Journal
Molecular ImmunologyVolume
45Issue
3Pagination
607 - 618Publisher
Pergamon PressLocation
Oxford, EnglandPublisher DOI
ISSN
0161-5890eISSN
1872-9142Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
Copyright 2007 Elsevier Ltd All rights reserved.Usage metrics
Categories
Keywords
CD8+ cellsT cell receptor repertoireCD62LMemoryInfluenza A virusScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyImmunologyCD8(+) cellsINFLUENZA-A VIRUSCYTOTOXIC LYMPHOCYTES-TEPSTEIN-BARR-VIRUSCOMPLEX CLASS-IRECEPTOR REPERTOIREANTIGEN RECEPTORRECALL RESPONSESTCR REPERTOIREIMMUNODOMINANT DETERMINANTCHORIOMENINGITIS VIRUSImmunology
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