File(s) under permanent embargo
Tunable biodegradable silk-based memory foams with controlled release of antibiotics
journal contribution
posted on 2020-01-01, 00:00 authored by L Chambre, R N Parker, Ben AllardyceBen Allardyce, F Valente, Rangam RajkhowaRangam Rajkhowa, R J Dilley, Xungai Wang, D L KaplanSustained, local delivery of the antibiotic ciprofloxacin under different formats from porous silk protein-based memory foam systems was studied. Similarly, protease XIV was incorporated during processing to provide control of the degradation kinetics of the silk materials. In vitro antibiotic release studies combined with degradation assessments were utilized to assess the mechanisms and kinetics of release from the silk materials. The sequestered protease XIV affected the degradation profiles of the silk foams yet did not impact the release kinetics of the ciprofloxacin, which was controlled by solubility and diffusion of the drug. The ability to tune the release of ciprofloxacin between 1 and 200 days, combined with the option to modulate the degradation rate up to 80% in 2 weeks via incorporation of a protease, suggests utility for drug release devices. Further, we anticipate that this approach could also be extended to other medical implant needs and other drugs.
History
Journal
ACS applied bio materialsVolume
3Issue
4Pagination
2466 - 2472Publisher
American Chemical SocietyLocation
Washington, D.C.Publisher DOI
ISSN
2576-6422Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
controlled releasesilkbiomaterialsantibioticdegradablememory foamScience & TechnologyTechnologyNanoscience & NanotechnologyMaterials Science, BiomaterialsScience & Technology - Other TopicsMaterials Sciencerummy foamENZYMATIC DEGRADATIONSUSTAINED-RELEASEIN-VITRODELIVERYCIPROFLOXACINNANOPARTICLESRESISTANCEHYDROGELSPROTEINS
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC