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Turning natural adaptations to oncogenic factors into an ally in the war against cancer
journal contribution
posted on 2018-07-01, 00:00 authored by M Vittecoq, M Giraudeau, T Sepp, D J Marcogliese, Marcel KlaassenMarcel Klaassen, F Renaud, Beata UjvariBeata Ujvari, F ThomasBoth field and experimental evolution studies have demonstrated that organisms naturally or artificially exposed to environmental oncogenic factors can, sometimes rapidly, evolve specific adaptations to cope with pollutants and their adverse effects on fitness. Although numerous pollutants are mutagenic and carcinogenic, little attention has been given to exploring the extent to which adaptations displayed by organisms living in oncogenic environments could inspire novel cancer treatments, through mimicking the processes allowing these organisms to prevent or limit malignant progression. Building on a substantial knowledge base from the literature, we here present and discuss this progressive and promising research direction, advocating closer collaboration between the fields of medicine, ecology, and evolution in the war against cancer.
History
Journal
Evolutionary applicationsVolume
11Issue
6Pagination
836 - 844Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
Link to full text
ISSN
1752-4563eISSN
1752-4571Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2018, The AuthorsUsage metrics
Keywords
cancer resistanceecotoxicolgyexperimental evolutionpollutionwildlifeScience & TechnologyLife Sciences & BiomedicineEvolutionary BiologyecotoxicologyKILLIFISH FUNDULUS-HETEROCLITUSPERCH PERCA-FLAVESCENSGENETIC DIVERSITYENVIRONMENTAL RADIATIONPOPULATION-STRUCTURECHIRONOMUS-RIPARIUSMETAL CONTAMINATIONCADMIUM RESISTANCEPESTICIDE EXPOSURETUMOR-SUPPRESSOREvolutionary BiologyGenetics
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