craig-twinstudiesfor-2018.pdf (608.7 kB)
Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions
journal contribution
posted on 2018-05-01, 00:00 authored by L Calais-Ferreira, V C Oliveira, Jeffrey CraigJeffrey Craig, L B Flander, J L Hopper, L F Teixeira-Salmela, P H Ferreira© 2017 Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia Background: Musculoskeletal conditions are highly prevalent in our ageing society and are therefore incurring substantial increases in population levels of years lived with disability (YLD). An evidence-based approach to the prognosis, prevention, and treatment of those disorders can allow an overall improvement in the quality of life of patients, while also softening the burden on national health care systems. Methods: In this Masterclass article, we provide an overview of the most relevant twin study designs, their advantages, limitations and major contributions to the investigation of traits related to the domain of musculoskeletal physical therapy. Conclusions: Twin studies can be an important scientific tool to address issues related to musculoskeletal conditions. They allow researchers to understand how genes and environment combine to influence human health and disease. Twin registries and international collaboration through existing networks can provide resources for achieving large sample sizes and access to expertise in study design and analysis of twin data.
History
Journal
Brazilian journal of physical therapyVolume
22Issue
3Pagination
184 - 189Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
Link to full text
ISSN
1413-3555eISSN
1809-9246Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2017, Associação Brasileira de Pesquisa e Pós-Graduação em FisioterapiaUsage metrics
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