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Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia

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journal contribution
posted on 2014-07-01, 00:00 authored by Z Chatterton, D Burke, K R Emslie, Jeffrey CraigJeffrey Craig, J Ng, David Ashley, F Mechinaud, R Saffery, N C Wong
DNA methylation biomarkers capable of diagnosis and subtyping have been found for many cancers. Fifteen such markers have previously been identified for pediatric acute lymphoblastic leukemia (ALL). Validation of these markers is necessary to assess their clinical utility for molecular diagnostics. Substantial efficiencies could be achieved with these DNA methylation markers for disease tracking with potential to replace patient-specific genetic testing.

History

Journal

Clinical chemistry

Volume

60

Issue

7

Pagination

995 - 1003

Publisher

American Society for Clinical Pathology

Location

Chicago, IL

eISSN

1530-8561

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2014, American Society for Clinical Pathology