ashley-validationofdna-2014.pdf (802.9 kB)
Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia
journal contribution
posted on 2014-07-01, 00:00 authored by Z Chatterton, D Burke, K R Emslie, Jeffrey CraigJeffrey Craig, J Ng, David Ashley, F Mechinaud, R Saffery, N C WongDNA methylation biomarkers capable of diagnosis and subtyping have been found for many cancers. Fifteen such markers have previously been identified for pediatric acute lymphoblastic leukemia (ALL). Validation of these markers is necessary to assess their clinical utility for molecular diagnostics. Substantial efficiencies could be achieved with these DNA methylation markers for disease tracking with potential to replace patient-specific genetic testing.
History
Journal
Clinical chemistryVolume
60Issue
7Pagination
995 - 1003Publisher
American Society for Clinical PathologyLocation
Chicago, ILPublisher DOI
Link to full text
eISSN
1530-8561Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, American Society for Clinical PathologyUsage metrics
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No categories selectedKeywords
AdolescentCase-Control StudiesChildChild, PreschoolDNA MethylationFalse Negative ReactionsFalse Positive ReactionsFemaleForkhead Transcription FactorsGene DosageGenetic MarkersHomeodomain ProteinsHumansInfantLimit of DetectionMaleNeoplasm, ResidualPrecursor Cell Lymphoblastic Leukemia-LymphomaPromoter Regions, GeneticReference StandardsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationScience & TechnologyLife Sciences & BiomedicineMedical Laboratory TechnologyMINIMAL RESIDUAL DISEASEPROMOTER HYPERMETHYLATIONMASS-SPECTROMETRYCHILDHOODCANCERGENEINACTIVATIONMGMTQUANTIFICATIONCHILDREN
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