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Visuospatial processing and the function of prefrontal-parietal networks in autism spectrum disorders: a functional MRI study
journal contribution
posted on 2006-08-01, 00:00 authored by Tim SilkTim Silk, Nicole Rinehart, J L Bradshaw, B Tonge, G Egan, M W O'Boyle, R CunningtonOBJECTIVE: Individuals with autism spectrum disorders typically have normal visuospatial abilities but impaired executive functioning, particularly in abilities related to working memory and attention. The aim of this study was to elucidate the functioning of frontoparietal networks underlying spatial working memory processes during mental rotation in persons with autism spectrum disorders. METHOD: Seven adolescent males with normal IQ with an autism spectrum disorder and nine age- and IQ-matched male comparison subjects underwent functional magnetic resonance imaging scans while performing a mental rotation task. RESULTS: The autism spectrum disorders group showed less activation in lateral and medial premotor cortex, dorsolateral prefrontal cortex, anterior cingulate gyrus, and caudate nucleus. CONCLUSIONS: The finding of less activation in prefrontal regions but not in parietal regions supports a model of dysfunction of frontostriatal networks in autism spectrum disorders.
History
Journal
American journal of psychiatryVolume
163Issue
8Pagination
1440 - 1443Publisher
American Psychiatric Association PublishingLocation
Arlington, Va.Publisher DOI
ISSN
0002-953XeISSN
1535-7228Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2006, American Psychiatric AssociationUsage metrics
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No categories selectedKeywords
AdolescentAutistic DisorderBrain MappingChildGyrus CinguliHumansImaging, Three-DimensionalIntelligence TestsMagnetic Resonance ImagingMaleMemoryNeural PathwaysParietal LobePattern Recognition, VisualPrefrontal CortexPsychomotor PerformanceReaction TimeSpace PerceptionTask Performance and AnalysisScience & TechnologyLife Sciences & BiomedicinePsychiatry
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