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Diagnostics and Therapeutics in Targeting HER2 Breast Cancer: A Novel Approach
journal contribution
posted on 2023-10-24, 00:24 authored by Chris Vi, Giovanni MandaranoGiovanni Mandarano, Sarah ShigdarSarah ShigdarBreast cancer is one of the most commonly occurring cancers in women globally and is the primary cause of cancer mortality in females. BC is highly heterogeneous with various phenotypic expressions. The overexpression of HER2 is responsible for 15–30% of all invasive BC and is strongly associated with malignant behaviours, poor prognosis and decline in overall survival. Molecular imaging offers advantages over conventional imaging modalities, as it provides more sensitive and specific detection of tumours, as these techniques measure the biological and physiological processes at the cellular level to visualise the disease. Early detection and diagnosis of BC is crucial to improving clinical outcomes and prognosis. While HER2-specific antibodies and nanobodies may improve the sensitivity and specificity of molecular imaging, the radioisotope conjugation process may interfere with and may compromise their binding functionalities. Aptamers are single-stranded oligonucleotides capable of targeting biomarkers with remarkable binding specificity and affinity. Aptamers can be functionalised with radioisotopes without compromising target specificity. The attachment of different radioisotopes can determine the aptamer’s functionality in the treatment of HER2(+) BC. Several HER2 aptamers and investigations of them have been described and evaluated in this paper. We also provide recommendations for future studies with HER2 aptamers to target HER2(+) BC.
History
Journal
International Journal of Molecular SciencesVolume
22Article number
6163Pagination
Jan-26Location
Basel, SwitzerlandPublisher DOI
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eISSN
1422-0067Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Keywords
antibodiesaptamersBiochemistry & Molecular Biologybreast cancercancerCELL-SELEXChemistryChemistry, MultidisciplinaryCONTRAST AGENTSdiagnosisHER2imagingIMAGING STRATEGIESIN-VITROLife Sciences & BiomedicineMETASTASISnanobodiesNUCLEIC-ACID APTAMERSPhysical SciencesradioisotopesradiolabellingScience & TechnologySELECTIVELY DELIVERSSYSTEMATIC EVOLUTIONTENASCIN-CTHERAPYGenetics
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